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University of Alberta

Publications

2026

6. Nuligonda, T., Kumar, G., Wang, J. W., Mahal, L. K., & Meanwell, M. W. A practical guide for the preparation of C4'-modified nucleoside analogues. Nat. Protoc. In press.

5. Mondal, S., Sahil, Brown, A. & Meanwell, M. W. Beneficial Role of Sacrificial Magnesium Anode Enables Electrochemical Precision Deutero-(Di)carboxylation for the Preparation of Deuterium-Labeled Medicinal Building Blocks. Nature Comm. 16, 2025

2025

4. Sarkar, S., Rohit & Meanwell, M. W. A chemoselective electrochemical birch carboxylation of pyridines Green Chem. Advance Article (2025).

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2024

3. Nuligonda, T., Kumar, G., Wang, J. W., Rajapaksha, D., Elayan, I. A., Demir, R., Meanwell, N. J., Wang, S. F., Mahal, L. K., Brown, A., & Meanwell, M. W. An Enantioselective and Modular Platform for C4'-Modified Nucleoside Analogue Synthesis Enabled by Intramolecular trans-acetalizations. Nat. Commun. 15, 7080 (2024).

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Featured by Folio, Global News, and Org. Chem. Highlights:

- Researchers devise a quicker, more efficient way to make life-saving molecules | Folio

- Health Matters: Making nucleoside analogues faster | Watch News Videos Online

- C-O Ring Construction: The Ramana Synthesis of Zingibergingerol A

For more papers please see ‪Michael W. Meanwell‬ - ‪Google Scholar‬

2023

2. Mondal, S., Sarkar, S., Wang, J. W., & Meanwell, M. W. (2023). A Selective and Mild Electrochemical Defluorinative Carboxylation for Late-Stage C (sp3)-F Bond Functionalization. Green Chemistry.

1. Mondal, S., Stevanovic, B., Butler, E., Wang, J. W., & Meanwell, M. W. (2023). Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions. Chemical Communications, 59(44), 6694-6697.

Selected works prior to UAlberta

Meanwell, M., Fehr, G., Ren, W., Adluri, B., Rose, V., Lehmann, J., ... & Britton, R. (2021). Diversity-oriented synthesis of glycomimetics. Communications Chemistry, 4(1), 96.

Saito, M., Kawamata, Y., Meanwell, M., Navratil, R., Chiodi, D., Carlson, E., ... & Baran, P. S. (2021). N-ammonium ylide mediators for electrochemical C–H oxidation. Journal of the American Chemical Society, 143(20), 7859-7867.

Meanwell, M., Silverman, S. M., Lehmann, J., Adluri, B., Wang, Y., Cohen, R., ... & Britton, R. (2020). A short de novo synthesis of nucleoside analogs. Science, 369(6504), 725-730.

Meanwell, M., Adluri, B. S., Yuan, Z., Newton, J., Prevost, P., Nodwell, M. B., ... & Britton, R. (2018). Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives. Chemical Science, 9(25), 5608-5613.

Meanwell, M., Lehmann, J., Eichenberger, M., Martin, R. E., & Britton, R. (2018). Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C–H bonds. Chemical Communications, 54(71), 9985-9988.

Meanwell, M., Sutherland, M., & Britton, R. (2018). Application of sequential proline-catalyzed α-chlorination and aldol reactions in the total synthesis of 1-deoxygalactonojirimycin. Canadian Journal of Chemistry, 96(2), 144-147.

Meanwell, M. W., O’Sullivan, C., Howard, P., & Fyles, T. M. (2017). Branched-chain and dendritic lipids for nanoparticles. Canadian Journal of Chemistry, 95(2), 120-129.

Meanwell, M., Nodwell, M. B., Martin, R. E., & Britton, R. (2016). A Convenient Late‐Stage Fluorination of Pyridylic C− H Bonds with N‐Fluorobenzenesulfonimide. Angewandte Chemie International Edition, 128(42), 13438-13442.

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